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Takao Someya

Professor
The University of Tokyo

Takao Someya received the Ph.D. degree in electrical engineering from the University of Tokyo in 1997. Since 2009, he has been a professor of Department of Electrical and Electronic Engineering, The University of Tokyo. From 2001 to 2003, he worked at the Nanocenter (NSEC) of Columbia University and Bell Labs, Lucent Technologies, as a Visiting Scholar.  His current research interests include organic transistors, flexible electronics, plastic integrated circuits, large-area sensors, and plastic actuators. electronics. He serves as the Project Leader of the NEDO/JAPERA Project (since March 2011) and Research Director of the “Conformal Bioimager” Project of the JST/ACCEL R&D Program (since July 2017). He has received a number of awards including a Japan Society for the Promotion of Science (JSPS) Prize in 2009 and 2009 IEEE Paul Rappaport Award. He is a global scholar of Princeton University, a member of the board of directors of the U.S. Materials Research Society from 2009 to 2011, and an IEEE/EDS Distinguished Lecturer since 2005. Prof. Someya’s “large-area sensor array” electronic thin film was featured in Time Magazine as one of its “Best Inventions of 2005” in its November 21st, 2005 issue.

Abstract

Title: “Stretchable nanomesh electronics for wearables and in vitro characterizations”

Stretchable electronics are expected to open up a new class of applications ranging from wearable electronics for health-monitoring and human-machine interfaces, implantable electronics, and in vitro characterization. Wearable technology can enable continuous, long-term monitoring and lead to the personalization of medical care that can help people stay healthy and prevent more serious health problems from happening in the first place. In order to expand emerging applications of wearable technologies, soft biomedical sensors have attracted much attention recently. In order to minimize the discomfort of wearing sensors, it is highly desirable to use soft electronic materials particularly for devices that come directly into contact with the skin and/or biological tissues. Thanks to recent progress of soft electronics, intimate and conformal integration of electronics with the human skin can be created to continuously monitor health conditions. It can monitor small changes that occur very gradually over long periods and, therefore, have tremendous potential to drastically change the nature of the examination and treatment of medical conditions. In this talk, recent progress and outlook of wearables using stretchable devices will be reviewed. In particular, I report a newly developed hypoallergenic electronic sensor that can be worn on the skin continuously for a week without discomfort. It is so light and thin that users forget they even have it on. The elastic electrode constructed of breathable nanoscale meshes holds promise for the development of noninvasive on-skin devices that can monitor a person's health continuously over a long period. Then, similar nanomesh sensors is applied to in vitro characterization. These can monitor the field potential of cardiomyocytes on gel, while enabling them to move dynamically without interference.

 


 

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Boris Murmann

Professor of Electrical Engineering
Stanford University, USA

Boris Murmann is a Professor of Electrical Engineering at Stanford University. He joined Stanford in 2004 after completing his Ph.D. degree in electrical engineering at the University of California, Berkeley in 2003. From 1994 to 1997, he was with Neutron Microelectronics, Germany, where he developed low-power and smart-power ASICs in automotive CMOS technology. Since 2004, he has worked as a consultant with numerous Silicon Valley companies. Dr. Murmann’s research interests are in mixed-signal integrated circuit design, with special emphasis on sensor interfaces, data converters and custom circuits for embedded machine learning. In 2008, he was a co-recipient of the Best Student Paper Award at the VLSI Circuits Symposium and a recipient of the Best Invited Paper Award at the IEEE Custom Integrated Circuits Conference (CICC). He received the Agilent Early Career Professor Award in 2009 and the Friedrich Wilhelm Bessel Research Award in 2012. He has served as an Associate Editor of the IEEE Journal of Solid-State Circuits, an AdCom member and Distinguished Lecturer of the IEEE Solid-State Circuits Society, as well as the Data Converter Subcommittee Chair and the Technical Program Chair of the IEEE International Solid-State Circuits Conference (ISSCC). He is the founding faculty co-director of the Stanford SystemX Alliance and the faculty director of Stanford's System Prototyping Facility (SPF). He is a Fellow of the IEEE.

Abstract

Title: "Mixed-Signal Circuit Techniques for Near-Sensor Machine Learning and Data Analysis"

Mixed-signal interfaces are the essential bridges between the physical world and the digital information processing backbone. In recent years, innovation in such interfaces has been increasingly fueled by application-level insight and the data-driven nature of modern systems. As a result, the traditional building block boundaries are blurring, and the extraction of information occurs through symbiotic interplay between analog and digital signal processing. In this talk, I will illustrate this trend using examples of small-scale machine learning and data analysis functions that operate at the physical interface. Specific examples include mixed-signal feature extraction circuits and compute fabric for machine learning inference, as well as data-compressive interfaces for high-dimensional sensor inputs.

 


 

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Luca Berdondini

Senior Researcher (Tenured), Head of the NetS3 Laboratory
Fondazione Istituto Italiano Di Tecnologia, Genova, Italy

Luca Berdondini is a Senior Researcher (with tenure) at the Fondazione Istituto Italiano di Tecnologia (Genova, Italy) where he leads the IIT-NetS3 laboratory. By converging cross-disciplinary engineering and neuroscience competences, including chip fabrication and bio-electrochemical sensor arrays, microelectronics and computational development, his research team focuses on the study and application of innovative neuroelectronic solutions for interfacing neural networks and brain circuits at cellular resolution. Luca Berdondini received in 1999 a M.Sc. degree in microengineering from the Swiss Federal Institute of Technology of Lausanne (EPFL) with a Master Thesis at Caltech (USA) and in 2003 a PhD on nano-/micro-fabricated interfaces and CMOS devices for electrophysiology (SAMLAB, now part of EPFL). He joined IIT in 2007 and he got a tenured position in 2018. He is among the pioneers of CMOS-based multielectrode arrays for electrophysiology, co-founder of 3Brain AG (Zurich, Switzerland) and he has contributed to >70 publications and patents.

Abstract

Title: "CMOS electrode array technologies to monitor neural activity for health and disease" 

The use of CMOS technology to realize active multielectrode array devices for large-scale neural interfacing with sub-millisecond and cellular resolutions is on the way to change how we can look at brain circuit’s and neural network’s activity. This is important to study their function in health and disease. In parallel, this highly integrated approach based on monolithic micro-/nano-structured CMOS devices is also providing innovative opportunities for the development of therapeutic strategies for brain diseases as well as small and ultra-low power devices for biomedical applications in diagnostics and prosthetics.
Planar CMOS devices with a high number of microelectrodes integrated in dense arrays at a pitch down to sub-cellular sizes were initially proposed for in-vitro preparations. Nowadays these planar CMOS multielectrode arrays (CMOS-MEAs) are commercially available and routinely used for studies and assays on cell cultures, organoids and brain tissues. More recently, implantable CMOS-probes for in-vivo recordings of neural activity were demonstrated for distributed recordings across superficial and deep brain circuits as well as in multiple brain regions. 
In this lecture we will review this technology and discuss our approach based on the Active Pixels Sensor (APS) circuit architecture to realize both planar and implantable CMOS-MEAs. This modular and scalable circuit solution allows continuous recordings from entire large arrays of closely spaced electrode-pixels and was recently demonstrated for recordings in rodents. The high data dimensionality provided by these new probes offers several advantages that can be exploited for pre-processing electrophysiological signals and to detect single-units activity. Finally, we will discuss ongoing developments toward wireless implantable probes for chronic brain interfaces and new generations of active micro-devices for high-throughput pre-clinical applications. 

 



 

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Hiro Yoshinari

Senior Vice President, Technology Development
Sysmex Corporation

Mr. Yoshinari is the Senior Vice President of Sysmex Corporation and the President of Creative Nanosystems.
He transferred from Sony at 2014 Jan.
In Sysmex, he is responsible for innovative activities for medical diagnostic products and ICT collaborative solution. The creative Nanosystems was established as a new venture company in ’18 Oct funded by Sysmex and JVCKenwood in the purpose of creating bio-devices for micro-fluidics base PoN.

In the former company, Sony, he had been managing 50 to 100 R&D members for nearly 8 years as General Manager. He led innovative technology development for professional contents creation products, then contributed its business growth through valance of technological competitiveness. Last 3 years, he challenged X-ray mammography efficiently using FPD technology and superior image processing technique. Unfortunately project was terminated but his curiosity about medical solution became bigger than ever.

He is now interested in adopting the best mix solution between diagnostic technology and ICT solution because everybody understands the medical scene is drastically changing recent years.
 

Abstract 

Title: “Digital transformation, our movement to the next medical and healthcare scene”

Transformation from medical care after becoming seriously ill caused by chronic disease to preventive and disease-free medical care is crucial theme in new medical and healthcare for mature society. The clinic-level medical care plays major role for it. Provision of solutions through the BestMix of PoN devices and ICTs strongly supports such trend.

We successfully realized compact and high sensitivity immunoassay system. We have adapted the CLEIA method with the Music CD shaped bio-device and network-connected 17cm Cube IoMT machine is implementing BestMix solutions with ICT-based services. It is very useful for monitoring the small molecules like cytokines related to chronic inflammation.

On the other hand, in order to verify the usefulness of our lifestyle habit management system for individualization prevention and medical care, we conducted a joint research with regional Hospital on the relationship between food content and postprandial blood glucose levels using our developed glucose patch test requires tissue fluid with ignorable invasion. As a result, we were able to making individual’s glucose tolerance profile. Being able to set dietary contents based on individual characteristics, it could be expected that more effective personalized dietary guidance.  By these results bring us another opportunity that we adapt to athlete's condition management, such as weight gain, weight loss and stamina UP using blood glucose level fluctuation. And we also monitor the athlete’s over training by utilizing immunology PoN.